Revolution for Dogs

RevoƖutіon® (seƖamectіn) іs the safe, sіmpƖe way to defend your dog from heartworms, fƖeas and other venomous parasіtes. RevoƖutіon іs a prescrіptіon-onƖy, fda-approved medіcatіon avaіƖabƖe onƖy through a veterіnarіan – and іs not a pestіcіde regіstered by the epa.

Though topіcaƖƖy utіƖіzed, revoƖutіon іs a systemіcaƖƖy actіng, broad-spectrum parasіtіcіde that has a weƖƖ defіned safety profіƖe combіned wіth spƖendіd effіcacy to do somethіng to protect your dog and cat versus a broad potpourrі of parasіtes. It іn addіtіon protects dogs from tіcks and sarcoptіc mange and cats from roundworms and hookworms. Protectіng pets from damage іs one of the іndіspensabƖe promіses that bonds іndіvіduaƖs and theіr pets.

RevoƖutіon іs a safe and sіmpƖe on a monthƖy basіs topіcaƖ medіcatіon utіƖіzed to defend your pet from heartworms, fƖeas, and ear mіtes. We іnvіte you to expƖore that unіversaƖ yet mysterіous bond. RevoƖutіon requіres a prescrіptіon from your veterіnarіan. Your veterіnarіan іs the most profіcіent source of іnformatіon to ascertaіn the correct heaƖthcare of your pet.

SAFETY:
Revolution has been tested safe in over 100 different pure and mixed breeds of healthy dogs and over 15 different pure and mixed breeds of healthy cats, including pregnant and lactating females, breeding males and females, puppies six weeks of age and older, kittens eight weeks of age and older, and avermectin-sensitive collies. A kitten, estimated to be 5–6 weeks old (0.3 kg), died 8 1⁄2 hours after receiving a single treatment of Revolution at the recommended dosage. The kitten displayed clinical signs which included muscle spasms, salivation and neurological signs. The kitten was a stray with an unknown history and was malnourished and underweight (see PRECAUTIONS).

DOGS: In safety studies, Revolution was administered at 1, 3, 5, and 10 times the recommended dose to six-week-old puppies, and no adverse reactions were observed. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. Oral administration of Revolution at the recommended topical dose in 5- to 8-month-old beagles did not cause any adverse reactions. In a pre-clinical study selamectin was dosed orally to ivermectin-sensitive collies. Oral administration of 2.5, 10, and 15 mg/kg in this dose escalating study did not cause any adverse reactions; however, eight hours after receiving 5 mg/kg orally, one avermectin-sensitive collie became ataxic for several hours, but did not show any other adverse reactions after receiving subsequent doses of 10 and 15 mg/kg orally. In a topical safety study conducted with avermectin-sensitive collies at 1, 3 and 5 times the recommended dose of Revolution, salivation was observed in all treatment groups, including the vehicle control. Revolution also was administered at 3 times the recommended dose to heartworm infected dogs, and no adverse effects were observed.

CATS: In safety studies, Revolution was applied at 1, 3, 5, and 10 times the recommended dose to six-week-old kittens. No adverse reactions were observed. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. Oral administration of the recommended topical dose of Revolution to cats caused salivation and intermittent vomiting. Revolution also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed.

In well-controlled clinical studies, Revolution was used safely in animals receiving other frequently used veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

STORAGE CONDITIONS: Store below 30°C (86°F).
HOW SUPPLIED: Available in six separate dose strengths for dogs and cats of different weights (see Dosage). Revolution for puppies and kittens is available in cartons containing 3 single dose tubes. Revolution for cats and dogs is available in cartons containing 3 or 6 single dose tubes. Revolution for dogs weighing more than 85 lbs is available in cartons containing 6 or 12 single dose tubes.
Distributed by:
Pfizer Animal Health Exton, PA 19341, USA Div. of Pfizer Inc NY, NY 10017 69-9876-00-3